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pentobarbital will lessen the extent or effect of voriconazole by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Mysterious.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can reduce panobinostat amounts by ~70% and produce procedu